Divulgazione Scientifica

2022

• In Silico, In Vitro, and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway

_{Anella Saviano ¹, Simona De Vita ², Maria Giovanna Chini ³, Noemi Marigliano ¹, Gianluigi Lauro ², Gian Marco Casillo ¹, Federica Raucci ¹, Maria Iorizzi ³, Robert Klaus Hofstetter ⁴, Katrin Fischer ⁴, Andreas Koeberle ⁵, Oliver Werz ⁴, Francesco Maione ¹, Giuseppe Bifulco ²}

• Carnosol Attenuates LPS-Induced Inflammation of Cardiomyoblasts by Inhibiting NF- κ B: A Mechanistic in Vitro and in Silico Study

_{Vafa Baradaran Rahimi ¹, Mohammad Amin Momeni-Moghaddam ², Maria Giovanna Chini ³, Anella Saviano ⁴, Francesco Maione ⁴, Giuseppe Bifulco ⁵, Pouria Rahmanian-Devin ⁶, Ali Jebalbarezy ⁶, Vahid Reza Askari ^6 7 8}

2021

• Interleukin-17A (IL-17A): A silent amplifier of COVID-19

_{Francesco Maione ¹, Gian Marco Casillo ¹, Federica Raucci ¹, Cristian Salvatore ², Giovanna Ambrosini ², Luisa Costa ³, Raffaele Scarpa ³, Francesco Caso ⁴, Mariarosaria Bucci ⁵}

• IL-17-induced inflammation modulates the mPGES-1/PPAR-γ pathway in monocytes/macrophages

_{Federica Raucci ¹, Anella Saviano ¹, Gian Marco Casillo ¹, Miguel Guerra-Rodriguez ², Adel Abo Mansour ^2 3, Marialuisa Piccolo ¹, Maria Grazia Ferraro ¹, Elisabetta Panza ¹, Valentina Vellecco ¹, Carlo Irace ¹, Francesco Caso ⁴, Raffaele Scarpa ⁴, Nicola Mascolo ¹, Mohammed Alfaifi ³, Asif Jilani Iqbal ^1 2, Francesco Maione ¹}

• Supplementation with ribonucleotide-based ingredient (Ribodiet®) lessens oxidative stress, brain inflammation, and amyloid pathology in a murine model of Alzheimer

_{Anella Saviano ¹, Gian Marco Casillo ¹, Federica Raucci ¹, Alessia Pernice ¹, Cristina Santarcangelo ², Marialuisa Piccolo ², Maria Grazia Ferraro ², Miriam Ciccone ³, Alessandro Sgherbini ⁴, Nadia Pedretti ⁴, Daniele Bonvicini ⁴, Carlo Irace ², Maria Daglia ², Nicola Mascolo ⁵, Francesco Maione ⁶}

• Galectin-9 Regulates Monosodium Urate Crystal-Induced Gouty Inflammation Through the Modulation of Treg/Th17 Ratio

_{Adel Abo Mansour ^1 2, Federica Raucci ³, Anella Saviano ³, Samantha Tull ¹, Francesco Maione ³, Asif Jilani Iqbal ^1 3}

• Safety and Efficacy Evaluation In Vivo of a Cationic Nucleolipid Nanosystem for the Nanodelivery of a Ruthenium(III) Complex with Superior Anticancer Bioactivity

_{Marialuisa Piccolo ¹, Maria Grazia Ferraro ¹, Federica Raucci ², Claudia Riccardi ³, Anella Saviano ², Irene Russo Krauss ^3 4, Marco Trifuoggi ³, Michele Caraglia ⁵, Luigi Paduano ^3 4, Daniela Montesarchio ³, Francesco Maione ², Gabriella Misso ⁵, Rita Santamaria ¹, Carlo Irace ¹}

2020

• Present Status and Future Trends of Natural-Derived Compounds Targeting T Helper (Th) 17 and Microsomal Prostaglandin E Synthase-1 (mPGES-1) as Alternative Therapies for Autoimmune and Inflammatory-Based Diseases

_{Anella Saviano ¹, Federica Raucci ¹, Gian Marco Casillo ¹, Chiara Indolfi ¹, Alessia Pernice ¹, Carmen Foreste ¹, Asif Jilani Iqbal ^1 2, Nicola Mascolo ¹, Francesco Maione ¹}

• Interleukin-17A (IL-17A), a key molecule of innate and adaptive immunity, and its potential involvement in COVID-19-related thrombotic and vascular mechanisms

_{Federica Raucci ¹, Adel Abo Mansour ², Gian Marco Casillo ¹, Anella Saviano ¹, Francesco Caso ³, Raffaele Scarpa ³, Nicola Mascolo ¹, Asif Jilani Iqbal ⁴, Francesco Maione ⁵}

• The functional link between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the onset of inflammation

_{Francesco Maione ¹, Gian Marco Casillo ², Federica Raucci ², Asif J Iqbal ³, Nicola Mascolo ²}

• Could IL-17 represent a new therapeutic target for the treatment and/or management of COVID-19-related respiratory syndrome?

_{Gian Marco Casillo ¹, Adel Abo Mansour ², Federica Raucci ¹, Anella Saviano ¹, Nicola Mascolo ¹, Asif Jilani Iqbal ³, Francesco Maione ⁴}

• Pharmacological and molecular docking assessment of cryptotanshinone as natural-derived analgesic compound

_{Carmen De Caro ¹, Federica Raucci ¹, Anella Saviano ¹, Claudia Cristiano ¹, Gian Marco Casillo ¹, Ritamaria Di Lorenzo ¹, Antonia Sacchi ¹, Sonia Laneri ¹, Irene Dini ¹, Simona De Vita ², Maria Giovanna Chini ³, Giuseppe Bifulco ⁴, Antonio Calignano ¹, Francesco Maione ⁵, Nicola Mascolo ¹}